Bacillus coagulans Unique IS-2®
Robust and stable — making it the probiotic for the challenging food and dietary supplement industries.
Check out the clinical studies
Of all probiotic species, the Bacillus species can withstand harsh manufacturing processes
A Unique Probiotic
High Tolerance & Stability
Bacillus coagulans or Lactobacillus sporogenes, as it was earlier known, is a high-temperature tolerant strain that sets it apart from most of the other probiotic strains – it does not need to be refrigerated and is shelf-stable.

The Protective Coating Difference
Bacillus coagulans Unique IS-2® is incredibly robust by virtue of it being encased in a hardened shell, which makes it the ideal strain for challenging product development projects. It is a gram-positive, facultative anaerobic, non-pathogenic, spore-forming, lactic acid-producing bacteria.
This probiotic bacteria is able to withstand harsh conditions, like acidic pH in the stomach, and as such is very effective towards stomach disorders and ailments.
Cell Wall
Inner Cell
Natural
Spore Coat

Unique IS-2® is a thoroughly researched probiotic strain with health benefits that span across health and nutrition
Backed by 25 Clinical Studies
Water
Stability of B. coagulans IS2 in water
Sports Drink
Unique IS2 showed 86% stability when tested in electrolyte drinks stored at 28°C for 6 months
Dark & Milk Chocolate
Unique IS2 maintained 100% stability in both dark and milk chocolate
Oats, Pasta, Jelly, & China Grass















Bacillus coagulans Unique IS-2® can be mixed with a variety of foods
Food Applications
It’s also available in various forms for ease of use
Nutraceuticals
Powder
Capsules
Tablets
Gums
Softgels
Drops
Sticks
Contact us to learn more
Unique IS-2® is a highly stable probiotic with a shelf-life of up to 3 years
Superior Stability
High Survivability
Can withstand the harsh environment of stomach acid (low pH) and bile juices to reach the intestine where it colonizes.
Highly Resilient
Can survive the shipping, manufacturing and transportation processes without significant loss and maximum retention of viability.
GRAS
Unique IS-2® is safe for consumption and has a GRAS no objection from US FDA.
Superior Viability
Stable at room temperature, requires no refrigeration.
Resistant to a Greater Range of Temperatures
Can survive a range of temperatures – high boiling to low freezing temperatures. This has wide applications in the food industry.
Needs No Microencapsulation
Makes it a cost effective probiotic which can be incorporated into a wide range of foods.
Compatible With
A variety of formats including gummies and tablets. Also compatible with vitamins, enzymes, electrolytes, proteins and carbohydrates.
Certified
Gluten free, vegan compliant, halal, and kosher.
Health Benefits
Our modern lifestyle has so many challenges which makes us susceptible to pathogenic bacteria resulting in a disrupted gut microbiome/dysbiosis and a weaker immune system. This is where Bacillus coagulans Unique IS-2® can provide support for normal functions.

Helps Reduce Bacterial Vaginosis
80% (16/20) subjects reported significant reduction in vaginosis symptoms compared to control group (45% only)
Helps Intestinal and Bowel Metabolism in Adults
Significant decrease in pain (0 = higher pain, 7 = lower pain)
Helps Intestinal and Bowel Metabolism in Children
Significant decrease in pain (0 = higher pain, 8 = lower pain)
Helps Support Healthy Liver Function
Positively impacts liver metabolism
Bacillus coagulans UNIQUE IS-2™ is a trademark of Unique Biotech Ltd, Licensed to Kaneka Americas Holding, Inc.