With the aging of the population, it is estimated that there will be 1.2 billion of menopausal women by the year 2030.
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KANEKA PROBIOTICS
KABP® Menopause
Probiotic for a balanced menopause journey
Outlook
The menopause support market holds big growth potential
There are around 50 symptoms associated with menopause. Many women have to live with these symptoms while remaining functional in their personal and professional lives.
Awareness of menopausal symptoms and long-term health implications continues to grow, with a shift of mentality towards solutions with a natural and holistic approach.
Women spend one-third of their lives in menopause.
Probiotics for menopause are an emerging category that has been gaining popularity, with growing consumer interest observed in the latter half of 2022. Online engagement has experienced a significant surge, particularly in Canada, where reviews skyrocketed by 440%, followed by the United Kingdom (200% growth) Brazil (50% growth), South Korea (42% growth), and Italy (33% growth).
The category of food supplements for menopausal symptoms reached 931 million dollars in sales in 2022 in the US.
KABP® Menopause naturally supports women during menopause, empowering them to embrace a fulfilling life.
The End of an Era
Menopausal symptoms can greatly disrupt a woman’s life.
Menopause is a natural biological process experienced by all aging women, that marks the end of their reproductive years.
Menopausal transition starts when the ovaries slow down their function, causing changes in several hormone levels including follicle-stimulating hormone (FSH), estrogen, and progesterone. It can last up to 10 to 15 years1.
The fall in estrogen at menopause results in many changes throughout women’s bodies, including physical and psychological symptoms that vary in severity, duration, and manifestation1.
Approximately 80% of women will experience noticeable symptoms during menopause that can impact their quality of life3.
High Survivability
Can withstand the harsh environment of stomach acid (low pH) and bile juices to reach the intestine where it colonizes.
GRAS
Unique IS2 is safe for consumption and has a GRAS no objection from US FDA
Resistant to a Greater Range of Temperatures
Can survive a range of temperatures – high boiling to low freezing temperatures. This has wide applications in the food industry.
Compatible With
A variety of formats including gummies and tablets. Also compatible with vitamins, enzymes, electrolytes, proteins and carbohydrates
Highly Resilient
Can survive the shipping, manufacturing and transportation processes without significant loss and maximum retention of viability
Superior Viability
Stable at room temperature,
requires no refrigeration
Needs No Microencapsulation
Makes it a cost effective probiotic which can be incorporated into a wide range of foods.
Certified
Gluten free, vegan compliant, halal, and kosher
Self Care
As a natural, biological process, menopause should be addressed with solutions.
Hormone replacement therapy (HRT) is considered the most effective option to manage common menopausal symptoms5, which comprises several drug treatments containing synthetic estrogen and/or progesterone. However, HRT is not a suitable treatment for everyone, and there are potential health risks associated with it.
Not for everyone
Women are now increasingly refusing to HRT and seeking natural alternatives for a safer, long-term approach to managing their menopause which include botanicals, vitamins, and probiotics.
Gut microbiota modulates estrogen levels in the gut.
Before being eliminated out of the body, estrogens are transformed into inactive forms by the liver. In the gut, estrogens can be rescued by specific commensal bacteria that convert estrogens into active molecules.
Estrogen reactivation occurs due to gut microbial b-glucuronidase (GUS) activity. In the gut, GUS activity facilitates the reabsorption of active estrogens in the bloodstream, contributing to the modulation of estrogen pool in the body.
During menopausal transition, the gut microbiota reduces its diversity and there is a loss of microbial GUS activity, which negatively impacts estrogen levels6.
A Better Way
KABP® Menopause slows down estrogen decline through GUS activity.
After an in vitro screening of over 80 bacterial strains from 16 different probiotic species, L. brevis KABP® 052 stood out with the strongest GUS activity.
Estrone and estradiol are two forms of estrogen that play crucial roles in the female body.
KABP® Menopause is a probiotic formulation demonstrated to modulate hormonal levels in a clinical trial.
Bring Balance to Your Body
Estrogen plays a crucial role in women’s health
Essential for the functioning of the reproductive system.
Contributes to skin hydration, elasticity and thickness, and hair growth and quality.
Maintains cognitive function, memory, and mood regulation.
Protects the cardiovascular system promoting healthy blood vessels and cholesterol levels.
Helps maintain bone density and strength.
Backed by 25 Clinical Studies
The strain L. brevis KABP® 052 demonstrated a significant ability to reactivate estrogens.
The ability of KABP® Menopause strains to reactivate estrogens was also studied. After 1 hour of incubation, L. brevis KABP® 052 produced significantly higher levels of deconjugated (active) estrogens than the other strains evaluated.
Water
Stability of B. coagulans IS2 in water
No Data Found
A clinical study found that KABP® Menopause reduces the decline in estrogen levels in menopausal women.
Dark & Milk Chocolate
Unique IS2 maintained 100% stability in both dark and milk chocolate
No Data Found
Oats, Pasta, Jelly, & China Grass
No Data Found
Results from a randomized, double-blind, placebo-controlled study in 113 healthy Japanese 45 to 55 yo women. Participants were administered 1 capsule a day of probiotic or placebo for 12 weeks. Several parameters were measured monthly, including changes in serum levels of hormones estrone (E1) and estradiol (E2).
Results
- Estrone and estradiol levels in placebo group were reduced at week 12 compared to baseline (#) while they were maintained in probiotic group
- The probiotic reduces the decline of E1 and E2 levels compared to placebo after 12 weeks of treatment.
There were no significant differences between the groups with respect to a reduction in menopause symptoms
KABP® Menopause is an ideal choice for several groups of women:
- Perimenopausal women who want to proactively manage their health and well-being throughout the menopause journey, seeking safe and effective products that may help enable them to maintain an active and healthy lifestyle.
- Peri- and post-menopausal women seeking alternative solutions to HRT who desire natural and effective remedies.
Start a New Chapter
KABP® Menopause: Proprietary, tailored probiotic formulation for a balanced menopause journey.
RECOMMENDED USE
- Once a day capsule
- Mix with:
- Vitamin B6 and Vitamin B9 – improves hot flashes, night sweats and mood disorders in menopausal women9,12.
- Vitamin D – supports bone health in postmenopausal women10.
References
1. Davis, S. R. et al. Menopause. Nat Rev Dis Primers 1, (2015). 2. Schoenaker, D. A. J. M., Jackson, C. A., Rowlands, J. V. & Mishra, G. D. Socioeconomic position, lifestyle factors and age at natural menopause: a systematic review and meta-analyses of studies across six continents. Int J Epidemiol 43, 1542–1562 (2014). 3. Menopause at work | TUC. https://www.tuc.org.uk/ menopause-work. 4. Manson, J. A. E. et al. Menopausal Hormone Therapy and Health Outcomes During the Intervention and Extended Poststopping Phases of the Women’s Health Initiative Randomized Trials. JAMA 310, 1353–1368 (2013). 5. Pinkerton, J. A. V. et al. The 2017 hormone therapy position statement of the North American Menopause Society. Menopause 24, 728–753 (2017). 6. Ervin, S. M. et al. Gut microbial β-glucuronidases reactivate estrogens as components of the estrobolome that reactivate estrogens. Journal of Biological Chemistry 294, 18586–18599 (2019). 7. Chen, P., Li, B. & Ou-Yang, L. Role of estrogen receptors in health and disease. Front Endocrinol (Lausanne) 13, (2022). 8. Odai, T. et al. Severity of hot flushes is inversely associated with dietary intake of vitamin B6 and oily fish. Climacteric 22, 617–621 (2019). 9. Management of osteoporosis in postmenopausal women: the 2021 position statement of The North American Menopause Society. Menopause 28, 973–997 (2021). 10. Lucas, M., Asselin, G., Merette, C., Poulin, M. J., & Dodin, S. (2009). Ethyl-eicosapentaenoic acid for the treatment of psychological distress and depressive symptoms in middle-aged women: a double-blind, placebo-controlled, randomized clinical trial. American Journal of Clinical Nutrition, 89(2), 641-651. 11. Honda et al. Supplementation with a probiotic blend increases serum estrogen levels in the peri/postmenopausal women. J Med Food (Accepted). 12. Bani S, Hasanpour S, Farzad Rik L, Hasankhani H, Sharami SH. The effect of folic Acid on menopausal hot flashes: a randomized clinical trial. J Caring Sci. 2013 Jun 1;2(2):131-40. doi: 10.5681/jcs.2013.016. PMID: 25276719; PMCID: PMC4161099.
