Probiotics for brain health

Cognitive health

Unlock the potential of the gut-brain axis

The gut-brain axis is a two-way signaling system between the gastrointestinal (GI) tract and central nervous system that is shown to influence mood, cognitive function and more. Growing research shows that brain function can be impacted by the gut microbiota.

Disruptions to the gut microbiota composition – known as dysbiosis – deregulate the pathways connecting the gut-brain axis. This can disturb the balance of the central nervous system; causing changes to the blood-brain barrier’s permeability.

Due to their positive influence on the gut microbiome, specific probiotic strains have been proposed to indirectly support cognitive function and mood. For this reason, there is a growing number of innovations in the space targeting stress and anxiety. Our portfolio of cognitive probiotic solutions is validated to enhance a number of mind functions, including memory, concentration and more.

Probiotic solutions for Cognitive health

KABP® Mindbiome

1 billion CFU/dose

A clinically studied probiotic that promotes a healthy digestive system and works along the gut-brain axis.

Indications

Shown to work along the gut-brain axis by increasing the production of enzymes involved in the serotonin production pathway
Supports a healthy GI tract
Helps alleviate/reduces stress in younger adults
Helps to improve social emotional cognition in healthy older adults
Supports mood

Probiotic Strains

Lactobacillus plantarum DR7®

Formats

Capsules, sticks

Learn more about KABP® Mindbiome See Clinical Evidence (5)

Clinical evidence

Clarke G, Grenham S, Scully P, Fitzgerald P, Moloney RD, Shanahan F, et al. The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner. Mol Psychiatry (2013).
Yano JM, Yu K, Donaldson GP, Shastri GG, Ann P, Ma L, et al. Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis. Cell (2015) 161:264–76.
De Vadder F, Kovatcheva-Datchary P, Goncalves D, Vinera J, Zitoun C, Duchampt A, et al. Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits. Cell (2014) 156:84–96.
Kim S, Kim H, Yim YS, Ha S, Atarashi K, Tan TG, et al. Maternal gut bacteria promote neurodevelopmental abnormalities in mouse offspring. Nature (2017) 549:528–32.
Sharon G, Sampson TR, Geschwind DH, Mazmanian SK. The Central Nervous System and the Gut Microbiome. Cell (2016) 167:915–32.
Singh V, Roth S, Llovera G, Sadler R, Garzetti D, Stecher B, et al. Microbiota dysbiosis controls the neuroinflammatory response after stroke. J Neurosci (2016) 36:7428–40.
Hsiao EY, McBride SW, Hsien S, Sharon G, Hyde ER, McCue T, et al. Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders. Cell (2013) 155:1451–63.
Valles-Colomer M, Falony G, Darzi Y, Tigchelaar EF, Wang J, Tito RY, et al. The neuroactive potential of the human gut microbiota in quality of life and depression. Nat Microbiol (2019) 4:623–32.
Zheng P, Zeng B, Liu M, Chen J, Pan J, Han Y, et al. The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice. Sci Adv (2019) 5:1–12.
Haran JP, Bhattarai SK, Foley SE, Dutta P, Ward DV, Bucci V, et al. crossm Alzheimer‘s Disease Microbiome Is Associated with. mBio (2019) 10:1–14.
Inserra A, Rogers GB, Licinio J, Wong ML. The Microbiota-Inflammasome Hypothesis of Major Depression. BioEssays (2018) 40:1–11.
Mayer, E. A. Gut feelings: The emerging biology of gut-“brain communication. Nature Reviews Neuroscience vol. 12 453–466 (2011).
Romijn, J. A, Corssmit, E. P., Havekes, L. M. & Pijl, H. Gut-brain axis. Current Opinion in Clinical Nutrition and Metabolic Care vol. 11 518–521 (2008).